Sixteen dogs were treated with drugs to see the effects on their blood histamine levels. The dogs were split into four groups: Two groups received the drugmorphine, and two received the drug trimethaphan, both given intravenously. For one group within each pair of drug groups, the dogs had their supply of histamine depleted before treatment, while the other group had histamine intact. (Measurements with the value "0.10" marked data that was missing and, were filled with that value arbitrarily.)
histamineA double matrix with 16 observations on the following 4 variables.
Histamine levels (in micrograms per milliliter of blood) before the inoculation.
Histamine levels (in micrograms per milliliter of blood) one minute after inoculation.
Histamine levels (in micrograms per milliliter of blood) three minute after inoculation.
Histamine levels (in micrograms per milliliter of blood) five minutes after inoculation.
Kenny J.Morris and Robert Zeppa. Histamine-induced hypotension due to morphine and arfonad in the dog. Journal of Surgical Research, 3(6):313-317, 1963.